1–6 In this approach, drug provocation tests (DPTs) are recommended mainly for either diagnosis of drug hypersensitivity or to provide safe alternatives as well as excluding cross-reactivity of related drugs in proven hypersensitivity.
NSAID CROSS REACTIVITY CHART SKIN
This requires a careful approach which includes the use of drug skin tests and provocation tests mainly oriented on the need of the patients. Management of hypersensitivity reactions to drugs is complex and has been a challenging area for allergists. However, these tests should be performed in hospital settings in which emergency equipment and experienced personnel are available. Our results suggest to follow the traditional DPT method to introduce COX-2 inhibitors for finding safe alternatives in all patients with cross-reactive NSAID hypersensitivity before prescription as uncertainty of any predictive factor for a positive response continues. None of the factors were found be associated with positive response. Twenty-five patients (30 provocations) reacted to COX-2 inhibitors. COX-2 inhibitors were well tolerated in the majority of the patients. The study group consisted of 309 patients. DPTs were single-blinded and placebo controlled. This study included the retrospective analysis of cases with cross-reactive NSAID hypersensitivity who underwent DPTs with COX-2 inhibitors in order to find safe alternatives. To document the safety of COX-2 inhibitors currently available and to check whether or not any factor predicts a positive response. However, cumulative data on encouraging results about the safety of COX-2 inhibitors in the majority of these patients bring the idea as to whether a DPT is always mandatory for introducing these drugs in all patients with cross-reactive NSAID hypersensitivity. These drugs are recommended to these patients after negative drug provocation tests (DPTs). See moreĬOX-2 inhibitors are safe alternatives in patients with cross-reactive non-steroidal anti-inflammatory drug (NSAID) hypersensitivity. Letters to the Editor on previously published papers are welcomed.Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.
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Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology. Manuscripts related to clinical, epidemiological and experimental allergology and childhood immunopathology will be considered for publication. Allergologia et Immunopathologia is no longer published on Elsevier since the 2021 year.Transferred to Codon PublicationsĪllergologia et Immunopathologia is a forum for those working in the field of asthma, allergy and immunology related to childhood.